Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

Limited understanding of bladder cancer aetiopathology hampers progress in reducing incidence. Mutational signatures show the anti-viral apolipoprotein B mRNA editing enzyme catalytic polypeptide (APOBEC) enzymes are responsible for the preponderance of mutations in bladder tumour genomes, but no ca...

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Detalles Bibliográficos
Autores principales: Baker, Simon C., Mason, Andrew S., Slip, Raphael G., Skinner, Katie T., Macdonald, Andrew, Masood, Omar, Harris, Reuben S., Fenton, Tim R., Periyasamy, Manikandan, Ali, Simak, Southgate, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862006/
https://www.ncbi.nlm.nih.gov/pubmed/35194151
http://dx.doi.org/10.1038/s41388-022-02235-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862006/
https://www.ncbi.nlm.nih.gov/pubmed/35194151
http://dx.doi.org/10.1038/s41388-022-02235-8

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