Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

The emergence of SARS-CoV-2 variants of concern (VOCs) requires the development of next-generation biologics that are effective against a variety of strains of the virus. Herein, we characterize a human V(H) domain, F6, which we generated by sequentially panning large phage displayed V(H) libraries...

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Detalles Bibliográficos
Autores principales: Chen, Chuan, Saville, James W., Marti, Michelle M., Schäfer, Alexandra, Cheng, Mary Hongying, Mannar, Dhiraj, Zhu, Xing, Berezuk, Alison M., Banerjee, Anupam, Sobolewski, Michele D., Kim, Andrew, Treat, Benjamin R., Da Silva Castanha, Priscila Mayrelle, Enick, Nathan, McCormick, Kevin D, Liu, Xianglei, Adams, Cynthia, Hines, Margaret Grace, Sun, Zehua, Chen, Weizao, Jacobs, Jana L., Barratt-Boyes, Simon M., Mellors, John W., Baric, Ralph S., Bahar, Ivet, Dimitrov, Dimiter S., Subramaniam, Sriram, Martinez, David R., Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863138/
https://www.ncbi.nlm.nih.gov/pubmed/35194603
http://dx.doi.org/10.1101/2022.02.18.481058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863138/
https://www.ncbi.nlm.nih.gov/pubmed/35194603
http://dx.doi.org/10.1101/2022.02.18.481058

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