PHF10 subunit of PBAF complex mediates transcriptional activation by MYC

The PBAF complex, a member of SWI/SNF family of chromatin remodelers, plays an essential role in transcriptional regulation. We revealed a disease progression associated elevation of PHF10 subunit of PBAF in clinical melanoma samples. In melanoma cell lines, PHF10 interacts with MYC and facilitates...

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Detalles Bibliográficos
Autores principales: Soshnikova, N.V., Tatarskiy, E.V., Tatarskiy, V.V., Klimenko, N.S., Shtil, A. A., Nikiforov, M.A., Georgieva, S.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863208/
https://www.ncbi.nlm.nih.gov/pubmed/34465901
http://dx.doi.org/10.1038/s41388-021-01994-0
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author Soshnikova, N.V.
Tatarskiy, E.V.
Tatarskiy, V.V.
Klimenko, N.S.
Shtil, A. A.
Nikiforov, M.A.
Georgieva, S.G.
author_facet Soshnikova, N.V.
Tatarskiy, E.V.
Tatarskiy, V.V.
Klimenko, N.S.
Shtil, A. A.
Nikiforov, M.A.
Georgieva, S.G.
author_sort Soshnikova, N.V.
collection PubMed
description The PBAF complex, a member of SWI/SNF family of chromatin remodelers, plays an essential role in transcriptional regulation. We revealed a disease progression associated elevation of PHF10 subunit of PBAF in clinical melanoma samples. In melanoma cell lines, PHF10 interacts with MYC and facilitates the recruitment of PBAF complex to target gene promoters, therefore augmenting MYC transcriptional activation of genes involved in the cell cycle progression. Depletion of either PHF10 or MYC induced G1 accumulation and a senescence-like phenotype. Our data identify PHF10 as a pro-oncogenic mechanism and an essential novel link between chromatin remodeling and MYC-dependent gene transcription.
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spelling pubmed-88632082022-02-28 PHF10 subunit of PBAF complex mediates transcriptional activation by MYC Soshnikova, N.V. Tatarskiy, E.V. Tatarskiy, V.V. Klimenko, N.S. Shtil, A. A. Nikiforov, M.A. Georgieva, S.G. Oncogene Article The PBAF complex, a member of SWI/SNF family of chromatin remodelers, plays an essential role in transcriptional regulation. We revealed a disease progression associated elevation of PHF10 subunit of PBAF in clinical melanoma samples. In melanoma cell lines, PHF10 interacts with MYC and facilitates the recruitment of PBAF complex to target gene promoters, therefore augmenting MYC transcriptional activation of genes involved in the cell cycle progression. Depletion of either PHF10 or MYC induced G1 accumulation and a senescence-like phenotype. Our data identify PHF10 as a pro-oncogenic mechanism and an essential novel link between chromatin remodeling and MYC-dependent gene transcription. 2021-10 2021-08-31 /pmc/articles/PMC8863208/ /pubmed/34465901 http://dx.doi.org/10.1038/s41388-021-01994-0 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
spellingShingle Article
Soshnikova, N.V.
Tatarskiy, E.V.
Tatarskiy, V.V.
Klimenko, N.S.
Shtil, A. A.
Nikiforov, M.A.
Georgieva, S.G.
PHF10 subunit of PBAF complex mediates transcriptional activation by MYC
title PHF10 subunit of PBAF complex mediates transcriptional activation by MYC
title_full PHF10 subunit of PBAF complex mediates transcriptional activation by MYC
title_fullStr PHF10 subunit of PBAF complex mediates transcriptional activation by MYC
title_full_unstemmed PHF10 subunit of PBAF complex mediates transcriptional activation by MYC
title_short PHF10 subunit of PBAF complex mediates transcriptional activation by MYC
title_sort phf10 subunit of pbaf complex mediates transcriptional activation by myc
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863208/
https://www.ncbi.nlm.nih.gov/pubmed/34465901
http://dx.doi.org/10.1038/s41388-021-01994-0
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