LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

The 2 major molecular switches in biology, kinases and GTPases, are both contained in the Parkinson disease–related leucine-rich repeat kinase 2 (LRRK2). Using hydrogen–deuterium exchange mass spectrometry (HDX-MS) and molecular dynamics (MD) simulations, we generated a comprehensive dynamic alloste...

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Detalles Bibliográficos
Autores principales: Weng, Jui-Hung, Aoto, Phillip C., Lorenz, Robin, Wu, Jian, Schmidt, Sven H., Manschwetus, Jascha T., Kaila-Sharma, Pallavi, Silletti, Steve, Mathea, Sebastian, Chatterjee, Deep, Knapp, Stefan, Herberg, Friedrich W., Taylor, Susan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863276/
https://www.ncbi.nlm.nih.gov/pubmed/35192607
http://dx.doi.org/10.1371/journal.pbio.3001427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863276/
https://www.ncbi.nlm.nih.gov/pubmed/35192607
http://dx.doi.org/10.1371/journal.pbio.3001427

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