A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants

The spike glycoprotein of SARS-CoV-2 engages with human ACE 2 to facilitate infection. Here, we describe an alpaca-derived heavy chain antibody fragment (VHH), saRBD-1, that disrupts this interaction by competitively binding to the spike protein receptor-binding domain. We further generated an engin...

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Detalles Bibliográficos
Autores principales: Weinstein, Jules B., Bates, Timothy A., Leier, Hans C., McBride, Savannah K., Barklis, Eric, Tafesse, Fikadu G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863326/
https://www.ncbi.nlm.nih.gov/pubmed/35224467
http://dx.doi.org/10.1016/j.isci.2022.103960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863326/
https://www.ncbi.nlm.nih.gov/pubmed/35224467
http://dx.doi.org/10.1016/j.isci.2022.103960

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