Cargando…

A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants

The spike glycoprotein of SARS-CoV-2 engages with human ACE 2 to facilitate infection. Here, we describe an alpaca-derived heavy chain antibody fragment (VHH), saRBD-1, that disrupts this interaction by competitively binding to the spike protein receptor-binding domain. We further generated an engin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weinstein, Jules B., Bates, Timothy A., Leier, Hans C., McBride, Savannah K., Barklis, Eric, Tafesse, Fikadu G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863326/ https://www.ncbi.nlm.nih.gov/pubmed/35224467 http://dx.doi.org/10.1016/j.isci.2022.103960

Ejemplares similares

Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum
por: Bates, Timothy A., et al.
Publicado: (2021)

Previously infected vaccinees broadly neutralize SARS-CoV-2 variants
por: Leier, Hans C., et al.
Publicado: (2021)

Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2
por: Bates, Timothy A., et al.
Publicado: (2021)

Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2
por: Bates, Timothy A., et al.
Publicado: (2020)

Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants
por: Bates, Timothy A., et al.
Publicado: (2022)

The time between vaccination and infection impacts immunity against SARS-CoV-2 variants
por: Bates, Timothy A., et al.
Publicado: (2023)

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies
por: Hanke, Leo, et al.
Publicado: (2022)

An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants
por: Bates, Timothy A., et al.
Publicado: (2023)

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
por: Hanke, Leo, et al.
Publicado: (2020)

Potent Neutralization of SARS-CoV-2 by Hetero-Bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain
por: Ma, Huan, et al.
Publicado: (2021)

Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum
por: Bates, Timothy A., et al.
Publicado: (2021)

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants
por: Farley, Scotland E., et al.
Publicado: (2022)

Omicron neutralizing antibody response following booster vaccination compared with breakthrough infection
por: Curlin, Marcel E., et al.
Publicado: (2022)

Omicron neutralizing antibody response following booster vaccination compared with breakthrough infection
por: Curlin, Marcel E., et al.
Publicado: (2022)

BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age
por: Bates, Timothy A., et al.
Publicado: (2022)

CAMEL NANOBODIES NEUTRALIZE SARS-COV-2 VARIANTS
por: Hong, Jessica, et al.
Publicado: (2023)

Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants
por: Yu, Bingchen, et al.
Publicado: (2022)

Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies
por: Stefan, Maxwell A., et al.
Publicado: (2021)

Development of humanized tri-specific nanobodies with potent neutralization for SARS-CoV-2
por: Dong, Jianbo, et al.
Publicado: (2020)

Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies
por: Güttler, Thomas, et al.
Publicado: (2021)

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes
por: Sun, Dapeng, et al.
Publicado: (2021)

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
por: Sun, Dapeng, et al.
Publicado: (2021)

A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants
por: Modhiran, Naphak, et al.
Publicado: (2023)

Camel nanobodies broadly neutralize SARS-CoV-2 variants
por: Hong, Jessica, et al.
Publicado: (2021)

Structural basis of nanobodies neutralizing SARS-CoV-2 variants
por: Shi, Zhenzhong, et al.
Publicado: (2022)

BNT162b2 induced neutralizing and non-neutralizing antibody functions against SARSCoV-2 diminish with age
por: Bates, Timothy A., et al.
Publicado: (2022)

A potent neutralizing nanobody against SARS‐CoV‐2 with inhaled delivery potential
por: Gai, Junwei, et al.
Publicado: (2021)

Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity
por: Chen, Wei-Hung, et al.
Publicado: (2023)

Generation of an alpaca-derived nanobody recognizing γ-H2AX
por: Rajan, Malini, et al.
Publicado: (2015)

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages
por: Bates, Timothy A, et al.
Publicado: (2023)

A global lipid map defines a network essential for Zika virus replication
por: Leier, Hans C., et al.
Publicado: (2020)

Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants
por: Hong, Jessica, et al.
Publicado: (2022)

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
por: Pymm, Phillip, et al.
Publicado: (2021)

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
por: Schoof, Michael, et al.
Publicado: (2020)

Author Correction: Development of humanized tri-specific nanobodies with potent neutralization for SARS-CoV-2
por: Dong, Jianbo, et al.
Publicado: (2021)

Lipids and pathogenic flaviviruses: An intimate union
por: Leier, Hans C., et al.
Publicado: (2018)

Ceramide synthase 2 deletion decreases the infectivity of HIV-1
por: Barklis, Eric, et al.
Publicado: (2021)

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants
por: Xu, Jianliang, et al.
Publicado: (2021)

Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis
por: Zupancic, Jennifer M., et al.
Publicado: (2021)

Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy
por: Adhikari, Emily H., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2cegk25usv0smhuhd3eejvhao5