Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression

Several pharmacogenetics studies have identified an association between a greater metformin-dependent reduction in HbA1c levels and the minor A allele at rs2289669 in intron 10 of SLC47A1, encoding multidrug and toxin extrusion 1 (MATE1), a presumed metformin transporter. It is currently unknown if...

Descripción completa

Detalles Bibliográficos
Autores principales: Kalamajski, Sebastian, Huang, Mi, Dalla-Riva, Jonathan, Keller, Maria, Dawed, Adem Y, Hansson, Ola, Pearson, Ewan R, Mulder, Hindrik, Franks, Paul W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863414/
https://www.ncbi.nlm.nih.gov/pubmed/34505146
http://dx.doi.org/10.1093/hmg/ddab266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863414/
https://www.ncbi.nlm.nih.gov/pubmed/34505146
http://dx.doi.org/10.1093/hmg/ddab266

Ejemplares similares