P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels

The P2X7 receptor is a critical purinergic receptor in immune cells. Its activation was associated with cathepsin release into macrophage cytosol, suggesting its involvement in lysosomal membrane permeabilization (LMP) and leakage. Nevertheless, the mechanisms by which P2X7 receptor activation induc...

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Detalles Bibliográficos
Autores principales: Santos, Stephanie Alexia Cristina Silva, Persechini, Pedro Muanis, Henriques-Santos, Bianca Monteiro, Bello-Santos, Victória Gabriela, Castro, Newton G., Costa de Sousa, Júlia, Genta, Fernando Ariel, Santiago, Marcelo Felippe, Coutinho-Silva, Robson, Savio, Luiz Eduardo Baggio, Kurtenbach, Eleonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863609/
https://www.ncbi.nlm.nih.gov/pubmed/35222364
http://dx.doi.org/10.3389/fimmu.2022.752105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863609/
https://www.ncbi.nlm.nih.gov/pubmed/35222364
http://dx.doi.org/10.3389/fimmu.2022.752105

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