Armored BCMA CAR T Cells Eliminate Multiple Myeloma and Are Resistant to the Suppressive Effects of TGF-β

CAR T-cell therapies targeting the B-cell maturation antigen eliminate tumors in relapsed/refractory multiple myeloma patients, however durable remissions remain difficult to attain. Transforming growth factor beta (TGF-β) is a multifunctional cytokine abundantly expressed in the multiple myeloma bo...

Descripción completa

Detalles Bibliográficos
Autores principales: Alabanza, Leah M., Xiong, Ying, Vu, Bang, Webster, Brian, Wu, Darong, Hu, Peirong, Zhu, Zhongyu, Dropulic, Boro, Dash, Pradyot, Schneider, Dina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863610/
https://www.ncbi.nlm.nih.gov/pubmed/35222421
http://dx.doi.org/10.3389/fimmu.2022.832645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863610/
https://www.ncbi.nlm.nih.gov/pubmed/35222421
http://dx.doi.org/10.3389/fimmu.2022.832645

Ejemplares similares