Genome‐wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores

Systolic and diastolic blood pressure (S/DBP) are highly correlated modifiable risk factors for cardiovascular disease (CVD). We report here a bidirectional Mendelian Randomization (MR) and horizontal pleiotropy analysis of S/DBP summary statistics from the UK Biobank (UKB)‐International Consortium...

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Detalles Bibliográficos
Autores principales: Zhu, Xiaofeng, Zhu, Luke, Wang, Heming, Cooper, Richard S., Chakravarti, Aravinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863647/
https://www.ncbi.nlm.nih.gov/pubmed/34989438
http://dx.doi.org/10.1002/gepi.22440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863647/
https://www.ncbi.nlm.nih.gov/pubmed/34989438
http://dx.doi.org/10.1002/gepi.22440

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