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Molecular and Cellular Mechanisms Underlying the Initiation and Progression of Alport Glomerular Pathology

Alport syndrome results from a myriad of variants in the COL4A3, COL4A4, or COL4A5 genes that encode type IV (basement membrane) collagens. Unlike type IV collagen α1(IV)(2)α2(IV)(1) heterotrimers, which are ubiquitous in basement membranes, α3/α4/α5 have a limited tissue distribution. The absence o...

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Detalles Bibliográficos
Autores principales: Cosgrove, Dominic, Madison, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863674/
https://www.ncbi.nlm.nih.gov/pubmed/35223933
http://dx.doi.org/10.3389/fmed.2022.846152