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Molecular and Cellular Mechanisms Underlying the Initiation and Progression of Alport Glomerular Pathology

Alport syndrome results from a myriad of variants in the COL4A3, COL4A4, or COL4A5 genes that encode type IV (basement membrane) collagens. Unlike type IV collagen α1(IV)(2)α2(IV)(1) heterotrimers, which are ubiquitous in basement membranes, α3/α4/α5 have a limited tissue distribution. The absence o...

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Detalles Bibliográficos
Autores principales:	Cosgrove, Dominic, Madison, Jacob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863674/ https://www.ncbi.nlm.nih.gov/pubmed/35223933 http://dx.doi.org/10.3389/fmed.2022.846152

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