Cargando…

Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status

Uterine leiomyomas (fibroids) are common benign tumors in women. The tryptophan metabolism through the kynurenine pathway plays important roles in tumorigenesis in general. Leiomyomas expressing mutated mediator complex subunit 12 (mut-MED12) were reported to contain significantly decreased tryptoph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hutchinson, Anne P., Yin, Ping, Neale, Ilona, Coon, John S., Kujawa, Stacy A., Liu, Shimeng, Bulun, Serdar E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Fibroid: Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863695/ https://www.ncbi.nlm.nih.gov/pubmed/35064560 http://dx.doi.org/10.1007/s43032-022-00852-y

Ejemplares similares

Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma
por: Liu, Shimeng, et al.
Publicado: (2018)

MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas
por: Zuberi, Azna, et al.
Publicado: (2023)

Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas
por: Chuang, Tsai-Der, et al.
Publicado: (2022)

FKBP51 Contributes to Uterine Leiomyoma Pathogenesis by Inducing Cell Proliferation and Extracellular Matrix Deposition
por: New, Erika P., et al.
Publicado: (2022)

Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation
por: Iizuka, Takashi, et al.
Publicado: (2022)

The Gut Microbiota: a Novel Player in the Pathogenesis of Uterine Fibroids
por: K, Vineetha K, et al.
Publicado: (2023)

THU625 Med12 Mutation Activates Tryptophan-Kynurenine-ahr Pathway To Promote Growth Of Uterine Leiomyoma
por: Zuberi, Azna, et al.
Publicado: (2023)

Targeting DNA Methylation Depletes Uterine Leiomyoma Stem Cell–enriched Population by Stimulating Their Differentiation
por: Liu, Shimeng, et al.
Publicado: (2020)

Progesterone receptor-DNA methylation crosstalk regulates depletion of uterine leiomyoma stem cells: A potential therapeutic target
por: Liu, Shimeng, et al.
Publicado: (2021)

Human Myometrial and Uterine Fibroid Stem Cell-Derived Organoids for Intervening the Pathophysiology of Uterine Fibroid
por: Banerjee, Saswati, et al.
Publicado: (2022)

Uterine Fibroids, Perceived Stress, and Menstrual Distress: a Key Role of Heavy Menstrual Bleeding
por: Vannuccini, Silvia, et al.
Publicado: (2022)

A Phase I Clinical Trial to Assess Safety and Tolerability of Injectable Collagenase in Women with Symptomatic Uterine Fibroids
por: Singh, Bhuchitra, et al.
Publicado: (2021)

Pressure-Induced Fibroid Ischemia: First-In-Human Experience with a Novel Device for Laparoscopic Treatment of Symptomatic Uterine Fibroids
por: Tal, Michael G., et al.
Publicado: (2022)

Role of Stem Cells in Human Uterine Leiomyoma Growth
por: Ono, Masanori, et al.
Publicado: (2012)

Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma
por: Xie, Jia, et al.
Publicado: (2018)

Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas
por: Vidimar, Vania, et al.
Publicado: (2016)

THU631 Steroyl-CoA Desaturase Is A Progesterone Receptor Target Gene In Uterine Leiomyoma
por: Komorowski, Allison S, et al.
Publicado: (2023)

A Call-to-Action for Clinicians to Implement Evidence-Based Best Practices When Caring for Women with Uterine Fibroids
por: Leyland, Nicholas, et al.
Publicado: (2022)

Exploring the mechanism of tryptophan 2,3-dioxygenase
por: Thackray, Sarah J., et al.
Publicado: (2008)

Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy
por: Brochez, Lieve, et al.
Publicado: (2021)

MED12 and HMGA2 mutations: Two independent genetic events in uterine leiomyoma and leiomyosarcoma
por: Bertsch, Elizabeth, et al.
Publicado: (2014)

Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
por: Moyo, Mthabisi B., et al.
Publicado: (2020)

A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases
por: Zhou, Qihui, et al.
Publicado: (2021)

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth
por: Ono, Masanori, et al.
Publicado: (2014)

Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function
por: Elbers, Frank, et al.
Publicado: (2016)

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma
por: Terai, Mizue, et al.
Publicado: (2020)

Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase
por: Yoshioka, Saeko, et al.
Publicado: (2022)

Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice
por: Maeta, Akihiro, et al.
Publicado: (2013)

Natural History of Uterine Fibroids: A Radiological Perspective
por: Ghosh, Srirupa, et al.
Publicado: (2018)

Genome-Wide DNA Methylation Indicates Silencing of Tumor Suppressor Genes in Uterine Leiomyoma
por: Navarro, Antonia, et al.
Publicado: (2012)

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer
por: Chen, I-Chien, et al.
Publicado: (2016)

Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepG2 Tumor Cells
por: Oweira, Hani, et al.
Publicado: (2022)

Influence of Tryptophan Contained in 1-Methyl-Tryptophan on Antimicrobial and Immunoregulatory Functions of Indoleamine 2,3-Dioxygenase
por: Schmidt, Silvia K., et al.
Publicado: (2012)

MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas
por: Kämpjärvi, Kati, et al.
Publicado: (2016)

Correction: Oweira et al. Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepaRG Tumor Cells. J. Clin. Med. 2022, 11, 4794
por: Oweira, Hani, et al.
Publicado: (2023)

MED12 exon 2 mutations are common in uterine leiomyomas from South African patients
por: Mäkinen, Netta, et al.
Publicado: (2011)

Comprehensive behavioral analysis of tryptophan 2,3‐dioxygenase (Tdo2) knockout mice
por: Hattori, Satoko, et al.
Publicado: (2018)

The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal
por: Badawy, Abdulla A-B, et al.
Publicado: (2019)

Dysregulation of Synaptic Signaling Genes Is Involved in Biology of Uterine Leiomyoma
por: Krsteski, Jovan, et al.
Publicado: (2021)

Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South Korean patients
por: Lee, Minkyoung, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_alit9hukm73i4e4m07ub4i8kfi