Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer

High-grade serous ovarian cancer (HGSOC) is an aggressive malignancy often diagnosed at an advanced stage. Although most HGSOC patients respond initially to debulking surgery combined with cytotoxic chemotherapy, many ultimately relapse with platinum-resistant disease. Thus, improving outcomes requi...

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Detalles Bibliográficos
Autores principales: Buensuceso, Adrian, Fritz, Jamie Lee, Collins, Olga, Valdés, Yudith Ramos, Borrelli, Matthew J., DiMattia, Gabriel E., Shepherd, Trevor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863794/
https://www.ncbi.nlm.nih.gov/pubmed/35194062
http://dx.doi.org/10.1038/s41598-022-06796-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863794/
https://www.ncbi.nlm.nih.gov/pubmed/35194062
http://dx.doi.org/10.1038/s41598-022-06796-2

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