Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma

Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC). We utilized Hjv(−/−) mice to dissect mechanisms for hepatocarcinogenesis. We show that suboptimal treatment with diethylnitrosamine (DEN) trigg...

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Detalles Bibliográficos
Autores principales: Allameh, Abdolamir, Hüttmann, Nico, Charlebois, Edouard, Katsarou, Angeliki, Gu, Wen, Gkouvatsos, Konstantinos, Pasini, Elisa, Bhat, Mamatha, Minic, Zoran, Berezovski, Maxim, Guido, Maria, Fillebeen, Carine, Pantopoulos, Kostas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863832/
https://www.ncbi.nlm.nih.gov/pubmed/35194137
http://dx.doi.org/10.1038/s42003-022-03108-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863832/
https://www.ncbi.nlm.nih.gov/pubmed/35194137
http://dx.doi.org/10.1038/s42003-022-03108-2

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