Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Co-stimulation is critical to the function of chimeric antigen receptor (CAR) T-cells. Previously, we demonstrated that dual co-stimulation can be effectively harnessed by a parallel (p)CAR architecture in which a CD28-containing second generation CAR is co-expressed with a 4-1BB containing chimeric...

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Detalles Bibliográficos
Autores principales: Halim, Leena, Das, Kushal K., Larcombe-Young, Daniel, Ajina, Adam, Candelli, Andrea, Benjamin, Reuben, Dillon, Richard, Davies, David M., Maher, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863855/
https://www.ncbi.nlm.nih.gov/pubmed/35222427
http://dx.doi.org/10.3389/fimmu.2022.836549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863855/
https://www.ncbi.nlm.nih.gov/pubmed/35222427
http://dx.doi.org/10.3389/fimmu.2022.836549

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