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Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation

Parkinson’s disease (PD) and Alzheimer’s disease (AD) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins, α-synuclein (aSyn) in PD, and amyloid-β (Aβ) and Tau in AD. Strikingly, few PD and AD patients’ brains exhibit pure pathology with most cases pres...

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Detalles Bibliográficos
Autores principales: Torres-Garcia, Laura, P. Domingues, Joana M., Brandi, Edoardo, Haikal, Caroline, Mudannayake, Janitha M., Brás, Inês C., Gerhardt, Ellen, Li, Wen, Svanbergsson, Alexander, Outeiro, Tiago F., Gouras, Gunnar K., Li, Jia-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863885/
https://www.ncbi.nlm.nih.gov/pubmed/35194057
http://dx.doi.org/10.1038/s41598-022-06846-9