Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4

RNA interference is required for post-transcriptional silencing, but also has additional roles in transcriptional silencing of centromeres and genome stability. However, these roles have been controversial in mammals. Strikingly, we found that Dicer-deficient embryonic stem cells have strong prolife...

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Detalles Bibliográficos
Autores principales: Gutbrod, M. J., Roche, B., Steinberg, J. I., Lakhani, A. A., Chang, K., Schorn, A. J., Martienssen, R. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863982/
https://www.ncbi.nlm.nih.gov/pubmed/35194019
http://dx.doi.org/10.1038/s41467-022-28554-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863982/
https://www.ncbi.nlm.nih.gov/pubmed/35194019
http://dx.doi.org/10.1038/s41467-022-28554-8

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