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Quercetin induces pannexin 1 expression via an alternative transcript with a translationally active 5′ leader in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a deadly cancer of skeletal muscle origin. Pannexin 1 (PANX1) is down-regulated in RMS and increasing its levels drastically inhibits RMS progression. PANX1 upregulation thus represents a prospective new treatment strategy for this malignancy. However, the mechanisms regula...
Autores principales: | Xiang, Xiao, Hoang, Huy-Dung, Gilchrist, Victoria H., Langlois, Stéphanie, Alain, Tommy, Cowan, Kyle N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864035/ https://www.ncbi.nlm.nih.gov/pubmed/35194046 http://dx.doi.org/10.1038/s41389-022-00384-9 |
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