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Bryostatin Activates CAR T-Cell Antigen-Non-Specific Killing (CTAK), and CAR-T NK-Like Killing for Pre-B ALL, While Blocking Cytolysis of a Burkitt Lymphoma Cell Line

The advent of CAR-T cell therapy has changed the face of clinical care for relapsed and refractory pre-B-acute lymphocytic leukemia (B-ALL) and lymphoma. Although curative responses are reported, long-term cures remain below 50%. Different CAR T-cell leukemia targets appear to have different mechani...

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Detalles Bibliográficos
Autores principales: Wang, Lingyan, Zhang, Yue, Anderson, Eden, Lamble, Adam, Orentas, Rimas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864095/
https://www.ncbi.nlm.nih.gov/pubmed/35222407
http://dx.doi.org/10.3389/fimmu.2022.825364