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Neoantigen Quantity and Quality in Relation to Pancreatic Cancer Survival

INTRODUCTION: Factors underlying antitumor immunity in pancreatic cancer (PC) are poorly understood. We hypothesized that not neoantigen quantity, but quality, is related to immune cell infiltration and survival. METHODOLOGY: We performed genomic and transcriptomic profiling of paired normal, tumor...

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Detalles Bibliográficos
Autores principales: Levink, Iris J. M., Brosens, Lodewijk A. A., Rensen, Sander S., Aberle, Merel R., Olde Damink, Steven S. W., Cahen, Djuna L., Buschow, Sonja I., Fuhler, Gwenny M., Peppelenbosch, Maikel P., Bruno, Marco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864178/
https://www.ncbi.nlm.nih.gov/pubmed/35223878
http://dx.doi.org/10.3389/fmed.2021.751110
Descripción
Sumario:INTRODUCTION: Factors underlying antitumor immunity in pancreatic cancer (PC) are poorly understood. We hypothesized that not neoantigen quantity, but quality, is related to immune cell infiltration and survival. METHODOLOGY: We performed genomic and transcriptomic profiling of paired normal, tumor tissue of 13 patients with PC with distinct survival times. Additionally, neoantigens prediction and immunological profiling were performed. RESULTS: The proportion of neoantigens with a low similarity-to-self score was higher in short-term survivors (p < 0.0001), while mutational load and burden, similarity-to-known-pathogens, and immunogenicity of neoantigens were not associated with immune cell infiltration or survival. DISCUSSION: No tumor mutational load or neoantigen quantity, but low similarity-to-self score, was associated with immune cell infiltration and survival.