Multiple Myeloma Patient Tumors With High Levels of Cereblon Exon-10 Deletion Splice Variant Upregulate Clinically Targetable Pro-Inflammatory Cytokine Pathways

Immunomodulatory drugs (IMiDs), including lenalidomide and pomalidomide, are used in the routine treatment for multiple myeloma (MM) patients. Cereblon (CRBN) is the direct molecular target of IMiDs. While CRBN is not an essential gene for MM cell proliferation, the frequency of CRBN genetic aberrat...

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Detalles Bibliográficos
Autores principales: Karagoz, Kubra, Stokes, Matthew, Ortiz-Estévez, María, Towfic, Fadi, Flynt, Erin, Gooding, Sarah, Pierceall, William, Thakurta, Anjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864318/
https://www.ncbi.nlm.nih.gov/pubmed/35222546
http://dx.doi.org/10.3389/fgene.2022.831779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864318/
https://www.ncbi.nlm.nih.gov/pubmed/35222546
http://dx.doi.org/10.3389/fgene.2022.831779

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