Identification of the first structurally validated covalent ligands of the small GTPase RAB27A

Rab27A is a small GTPase, which mediates transport and docking of secretory vesicles at the plasma membrane via protein–protein interactions (PPIs) with effector proteins. Rab27A promotes the growth and invasion of multiple cancer types such as breast, lung and pancreatic, by enhancing secretion of...

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Detalles Bibliográficos
Autores principales: Jamshidiha, Mostafa, Lanyon-Hogg, Thomas, Sutherell, Charlotte L., Craven, Gregory B., Tersa, Montse, De Vita, Elena, Brustur, Delia, Pérez-Dorado, Inmaculada, Hassan, Sarah, Petracca, Rita, Morgan, Rhodri M., Sanz-Hernández, Máximo, Norman, Jim C., Armstrong, Alan, Mann, David J., Cota, Ernesto, Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864489/
https://www.ncbi.nlm.nih.gov/pubmed/35308027
http://dx.doi.org/10.1039/d1md00225b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864489/
https://www.ncbi.nlm.nih.gov/pubmed/35308027
http://dx.doi.org/10.1039/d1md00225b

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