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Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates
The introduction of glycoconjugate vaccines marks an important point in the fight against various infectious diseases. The covalent conjugation of relevant polysaccharide antigens to immunogenic carrier proteins enables the induction of a long-lasting and robust IgG antibody response, which is not o...
Autores principales: | Carboni, Filippo, Kitowski, Annabel, Sorieul, Charlotte, Veggi, Daniele, Marques, Marta C., Oldrini, Davide, Balducci, Evita, Brogioni, Barbara, Del Bino, Linda, Corrado, Alessio, Angiolini, Francesca, Dello Iacono, Lucia, Margarit, Immaculada, Romano, Maria Rosaria, Bernardes, Gonçalo J. L., Adamo, Roberto |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864718/ https://www.ncbi.nlm.nih.gov/pubmed/35310500 http://dx.doi.org/10.1039/d1sc01928g |
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