Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors‏ on PC12 cells

BACKGROUND: The loss of cholinergic neurotransmission in Alzheimer's disease (AD) patients' brain is accompanied by a reduced concentration of Acetylcholine (ACh) within synaptic clefts. Thus, the use of acetylcholinesterase inhibitors (AChEIs) to block the cholinergic degradation of ACh i...

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Detalles Bibliográficos
Autores principales: Taheri, Maryam, Aslani, Samira, Ghafouri, Hossein, Mohammadi, Asadollah, Akbary Moghaddam, Vaha, Moradi, Nastarn, Naeimi, Hananeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864858/
https://www.ncbi.nlm.nih.gov/pubmed/35193649
http://dx.doi.org/10.1186/s13065-022-00799-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864858/
https://www.ncbi.nlm.nih.gov/pubmed/35193649
http://dx.doi.org/10.1186/s13065-022-00799-w

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