Short divalent ethacrynic amides as pro-inhibitors of glutathione S-transferase isozyme Mu and potent sensitisers of cisplatin-resistant ovarian cancers

The linking of ethacrynic acid with ethylenediamine and 1,4-butanediamine gave EDEA and BDEA, respectively, as membrane-permeable divalent pro-inhibitors of glutathione S-transferase (GST). Their divalent glutathione conjugates showed subnanomolar inhibition and divalence-binding to GSTmu (GSTM) (PD...

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Detalles Bibliográficos
Autores principales: Xu, Bangtian, Tong, Tingting, Wang, Xin, Liu, Fang, Zhang, Xiang, Hu, Xiaolei, Li, Xinpeng, Yang, Xiaolan, Liao, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865112/
https://www.ncbi.nlm.nih.gov/pubmed/35176963
http://dx.doi.org/10.1080/14756366.2022.2038591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865112/
https://www.ncbi.nlm.nih.gov/pubmed/35176963
http://dx.doi.org/10.1080/14756366.2022.2038591

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