LRRK2 is required for CD38-mediated NAADP-Ca(2+) signaling and the downstream activation of TFEB (transcription factor EB) in immune cells

CD38 is a cell surface receptor capable of generating calcium-mobilizing second messengers. It has been implicated in host defense and cancer biology, but signaling mechanisms downstream of CD38 remain unclear. Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most common genetic cause of Pa...

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Detalles Bibliográficos
Autores principales: Nabar, Neel R., Heijjer, Christopher N., Shi, Chong-Shan, Hwang, Il-Young, Ganesan, Sundar, Karlsson, Mikael C. I., Kehrl, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865229/
https://www.ncbi.nlm.nih.gov/pubmed/34313548
http://dx.doi.org/10.1080/15548627.2021.1954779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865229/
https://www.ncbi.nlm.nih.gov/pubmed/34313548
http://dx.doi.org/10.1080/15548627.2021.1954779

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