Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells

The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers. Here, we report that transcript levels of ITGB6 (encoding the β6 integrin subunit) are significantly increased i...

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Detalles Bibliográficos
Autores principales: Krishn, Shiv Ram, Garcia, Vaughn, Naranjo, Nicole M., Quaglia, Fabio, Shields, Christopher D., Harris, Maisha A., Kossenkov, Andrew V., Liu, Qin, Corey, Eva, Altieri, Dario C., Languino, Lucia R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865252/
https://www.ncbi.nlm.nih.gov/pubmed/35188070
http://dx.doi.org/10.1080/15384047.2022.2030622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865252/
https://www.ncbi.nlm.nih.gov/pubmed/35188070
http://dx.doi.org/10.1080/15384047.2022.2030622

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