Flexible pri-miRNA structures enable tunable production of 5’ isomiRs

The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed a systematic analysis of the maturation of en...

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Detalles Bibliográficos
Autores principales: Bofill-De Ros, Xavier, Hong, Zhenyi, Birkenfeld, Ben, Alamo-Ortiz, Sarangelica, Yang, Acong, Dai, Lisheng, Gu, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865264/
https://www.ncbi.nlm.nih.gov/pubmed/35188062
http://dx.doi.org/10.1080/15476286.2022.2025680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865264/
https://www.ncbi.nlm.nih.gov/pubmed/35188062
http://dx.doi.org/10.1080/15476286.2022.2025680

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