Cargando…

Flexible pri-miRNA structures enable tunable production of 5’ isomiRs

The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed a systematic analysis of the maturation of en...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bofill-De Ros, Xavier, Hong, Zhenyi, Birkenfeld, Ben, Alamo-Ortiz, Sarangelica, Yang, Acong, Dai, Lisheng, Gu, Shuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865264/ https://www.ncbi.nlm.nih.gov/pubmed/35188062 http://dx.doi.org/10.1080/15476286.2022.2025680

Ejemplares similares

isomiRs: Increasing Evidences of isomiRs Complexity in Plant Stress Functional Biology
por: Sablok, Gaurav, et al.
Publicado: (2015)

Plant IsomiR Atlas: Large Scale Detection, Profiling, and Target Repertoire of IsomiRs in Plants
por: Yang, Kun, et al.
Publicado: (2019)

A Review of IsomiRs in Colorectal Cancer
por: Lausten, Molly A., et al.
Publicado: (2023)

Diff isomiRs: Large-scale detection of differential isomiRs for understanding non-coding regulated stress omics in plants
por: Yang, Kun, et al.
Publicado: (2019)

isomiR-SEA: an RNA-Seq analysis tool for miRNAs/isomiRs expression level profiling and miRNA-mRNA interaction sites evaluation
por: Urgese, Gianvito, et al.
Publicado: (2016)

Population variation in miRNAs and isomiRs and their impact on human immunity to infection
por: Rotival, Maxime, et al.
Publicado: (2020)

Reassessment of miRNA variant (isomiRs) composition by small RNA sequencing
por: Gómez-Martín, Cristina, et al.
Publicado: (2023)

isomiRs–Hidden Soldiers in the miRNA Regulatory Army, and How to Find Them?
por: Glogovitis, Ilias, et al.
Publicado: (2020)

An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
por: van der Kwast, Reginald V.C.T., et al.
Publicado: (2019)

Rapid and accurate quantification of isomiRs by RT-qPCR
por: Franco, Sandra, et al.
Publicado: (2022)

Differential expression patterns of conserved miRNAs and isomiRs during Atlantic halibut development
por: Bizuayehu, Teshome T, et al.
Publicado: (2012)

Circulating miRNAs, isomiRs and small RNA clusters in human plasma and breast milk
por: Rubio, Mercedes, et al.
Publicado: (2018)

Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs
por: Giuliani, Angelica, et al.
Publicado: (2020)

Bacterial Infection Drives the Expression Dynamics of microRNAs and Their isomiRs
por: Siddle, Katherine J., et al.
Publicado: (2015)

Hi-fidelity discrimination of isomiRs using G-quadruplex gatekeepers
por: Seow, Nianjia, et al.
Publicado: (2017)

Expression profiling of microRNAs and isomiRs in conventional central chondrosarcoma
por: Parafioriti, Antonina, et al.
Publicado: (2020)

Identification and Elucidation of the Protective isomiRs in Lung Cancer Patient Prognosis
por: Hsieh, Fu-Mei, et al.
Publicado: (2021)

Emerging Role of isomiRs in Cancer: State of the Art and Recent Advances
por: Zelli, Veronica, et al.
Publicado: (2021)

The MicroRNA Family Gets Wider: The IsomiRs Classification and Role
por: Tomasello, Luisa, et al.
Publicado: (2021)

Regulation of Huntingtin Gene Expression by miRNA-137, -214, -148a, and Their Respective isomiRs
por: Kozlowska, Emilia, et al.
Publicado: (2013)

A comprehensive analysis of miRNA/isomiRs profile of hydrosalpinx patients with interventional ultrasound sclerotherapy
por: Cao, Zhengyi, et al.
Publicado: (2022)

The Role of miRNAs, miRNA Clusters, and isomiRs in Development of Cancer Stem Cell Populations in Colorectal Cancer
por: Stark, Victoria A., et al.
Publicado: (2021)

miRNA arm selection and isomiR distribution in gastric cancer
por: Li, Sung-Chou, et al.
Publicado: (2012)

MicroRNAs and their isomiRs function cooperatively to target common biological pathways
por: Cloonan, Nicole, et al.
Publicado: (2011)

Sequence Features of Drosha and Dicer Cleavage Sites Affect the Complexity of IsomiRs
por: Starega-Roslan, Julia, et al.
Publicado: (2015)

Correction: Bacterial Infection Drives the Expression Dynamics of microRNAs and Their isomiRs
Publicado: (2015)

Non-invasive prostate cancer detection by measuring miRNA variants (isomiRs) in urine extracellular vesicles
por: Koppers-Lalic, Danijela, et al.
Publicado: (2016)

miR-isomiRExp: a web-server for the analysis of expression of miRNA at the miRNA/isomiR levels
por: Guo, Li, et al.
Publicado: (2016)

A Comprehensive Approach to Sequence-oriented IsomiR annotation (CASMIR): demonstration with IsomiR profiling in colorectal neoplasia
por: Wu, Chung Wah, et al.
Publicado: (2018)

A Comprehensive Analysis of miRNA/isomiR Expression with Gender Difference
por: Guo, Li, et al.
Publicado: (2016)

A deep learning method for miRNA/isomiR target detection
por: Talukder, Amlan, et al.
Publicado: (2022)

Genetic Regulation of Human isomiR Biogenesis
por: Jiang, Guanglong, et al.
Publicado: (2023)

Circulating microRNA/isomiRs as novel biomarkers of esophageal squamous cell carcinoma
por: Ibuki, Yuta, et al.
Publicado: (2020)

Global profiling and annotation of templated isomiRs dynamics across Caenorhabditis elegans development
por: Panzade, Ganesh, et al.
Publicado: (2022)

Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires
por: Bofill-De Ros, Xavier, et al.
Publicado: (2019)

Expanding the miRNA Repertoire in Atlantic Salmon; Discovery of IsomiRs and miRNAs Highly Expressed in Different Tissues and Developmental Stages
por: Woldemariam, Nardos Tesfaye, et al.
Publicado: (2019)

isomiRTar: a comprehensive portal of pan-cancer 5′-isomiR targeting
por: Nersisyan, Stepan, et al.
Publicado: (2022)

Jasmine: a Java pipeline for isomiR characterization in miRNA-Seq data
por: Zhong, Xiangfu, et al.
Publicado: (2020)

Evolutionary and Expression Analysis of miR-#-5p and miR-#-3p at the miRNAs/isomiRs Levels
por: Guo, Li, et al.
Publicado: (2015)

miRNAs and isomiRs: Serum-Based Biomarkers for the Development of Intellectual Disability and Autism Spectrum Disorder in Tuberous Sclerosis Complex
por: Scheper, Mirte, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tec75fslg84jvhuabfhdl6tt1g