VCP/p97 cofactor UBXN1/SAKS1 regulates mitophagy by modulating MFN2 removal from mitochondria

Initiation of PINK1- and PRKN-dependent mitophagy is a highly regulated process involving the activity of the AAA-ATPase VCP/p97, a cofactor-guided multifunctional protein central to handling ubiquitinated client proteins. Removal of ubiquitinated substrates such as the mitofusin MFN2 from the outer...

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Detalles Bibliográficos
Autores principales: Mengus, Chantal, Neutzner, Melanie, Bento, Ana Catarina Pinho Ferreira, Bippes, Claudia C., Kohler, Corina, Decembrini, Sarah, Häusel, Jessica, Hemion, Charles, Sironi, Lara, Frank, Stephan, Scholl, Hendrik P. N., Neutzner, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865314/
https://www.ncbi.nlm.nih.gov/pubmed/33966597
http://dx.doi.org/10.1080/15548627.2021.1922982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865314/
https://www.ncbi.nlm.nih.gov/pubmed/33966597
http://dx.doi.org/10.1080/15548627.2021.1922982

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