Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex

The single-stranded DNA genome of adeno-associated viruses (AAV) undergoes second-strand synthesis and transcription in the host cell nucleus. While wild-type AAV genomes are naturally silenced upon integration into the host genome, recombinant AAV (rAAV) genomes typically provide robust expression...

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Detalles Bibliográficos
Autores principales: Das, Anshuman, Vijayan, Madhuvanthi, Walton, Eric M., Stafford, V. Grace, Fiflis, David N., Asokan, Aravind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865469/
https://www.ncbi.nlm.nih.gov/pubmed/34878926
http://dx.doi.org/10.1128/jvi.02039-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865469/
https://www.ncbi.nlm.nih.gov/pubmed/34878926
http://dx.doi.org/10.1128/jvi.02039-21

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