SUMOylation of Matrix Protein M1 and Filamentous Morphology Collectively Contribute to the Replication and Virulence of Highly Pathogenic H5N1 Avian Influenza Viruses in Mammals

The matrix protein (M1) of influenza A virus plays an important role in replication, assembly, and budding. A previous study found that aspartic acid (D) at position 30 and alanine (A) at position 215 of M1 contribute to the high pathogenicity of H5N1 viruses in mice, and double mutations of D to as...

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Detalles Bibliográficos
Autores principales: Guo, Jing, Chen, Jianing, Li, Yuanyuan, Li, Yanbing, Deng, Guohua, Shi, Jianzhong, Liu, Liling, Chen, Hualan, Li, Xuyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865470/
https://www.ncbi.nlm.nih.gov/pubmed/34908445
http://dx.doi.org/10.1128/jvi.01630-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865470/
https://www.ncbi.nlm.nih.gov/pubmed/34908445
http://dx.doi.org/10.1128/jvi.01630-21

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