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SUMOylation of Matrix Protein M1 and Filamentous Morphology Collectively Contribute to the Replication and Virulence of Highly Pathogenic H5N1 Avian Influenza Viruses in Mammals
The matrix protein (M1) of influenza A virus plays an important role in replication, assembly, and budding. A previous study found that aspartic acid (D) at position 30 and alanine (A) at position 215 of M1 contribute to the high pathogenicity of H5N1 viruses in mice, and double mutations of D to as...
Autores principales: | Guo, Jing, Chen, Jianing, Li, Yuanyuan, Li, Yanbing, Deng, Guohua, Shi, Jianzhong, Liu, Liling, Chen, Hualan, Li, Xuyong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865470/ https://www.ncbi.nlm.nih.gov/pubmed/34908445 http://dx.doi.org/10.1128/jvi.01630-21 |
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