Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus

Antimicrobial resistance presents a significant health care crisis. The mutation F98Y in Staphylococcus aureus dihydrofolate reductase (SaDHFR) confers resistance to the clinically important antifolate trimethoprim (TMP). Propargyl-linked antifolates (PLAs), next generation DHFR inhibitors, are much...

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Detalles Bibliográficos
Autores principales: Wang, Siyu, Reeve, Stephanie M., Holt, Graham T., Ojewole, Adegoke A., Frenkel, Marcel S., Gainza, Pablo, Keshipeddy, Santosh, Fowler, Vance G., Wright, Dennis L., Donald, Bruce R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865654/
https://www.ncbi.nlm.nih.gov/pubmed/35143481
http://dx.doi.org/10.1371/journal.pcbi.1009855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865654/
https://www.ncbi.nlm.nih.gov/pubmed/35143481
http://dx.doi.org/10.1371/journal.pcbi.1009855

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