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Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus

Antimicrobial resistance presents a significant health care crisis. The mutation F98Y in Staphylococcus aureus dihydrofolate reductase (SaDHFR) confers resistance to the clinically important antifolate trimethoprim (TMP). Propargyl-linked antifolates (PLAs), next generation DHFR inhibitors, are much...

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Detalles Bibliográficos
Autores principales:	Wang, Siyu, Reeve, Stephanie M., Holt, Graham T., Ojewole, Adegoke A., Frenkel, Marcel S., Gainza, Pablo, Keshipeddy, Santosh, Fowler, Vance G., Wright, Dennis L., Donald, Bruce R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865654/ https://www.ncbi.nlm.nih.gov/pubmed/35143481 http://dx.doi.org/10.1371/journal.pcbi.1009855

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