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Machine learning modeling of family wide enzyme-substrate specificity screens

Biocatalysis is a promising approach to sustainably synthesize pharmaceuticals, complex natural products, and commodity chemicals at scale. However, the adoption of biocatalysis is limited by our ability to select enzymes that will catalyze their natural chemical transformation on non-natural substr...

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Detalles Bibliográficos
Autores principales: Goldman, Samuel, Das, Ria, Yang, Kevin K., Coley, Connor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865696/
https://www.ncbi.nlm.nih.gov/pubmed/35143485
http://dx.doi.org/10.1371/journal.pcbi.1009853