In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles

Simultaneous delivery of mRNA to multiple populations of antigen (Ag)–specific CD8(+) T cells is challenging given the diversity of peptide epitopes and polymorphism of class I major histocompatibility complexes (MHCI). We developed Ag-presenting nanoparticles (APNs) for mRNA delivery using pMHCI mo...

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Detalles Bibliográficos
Autores principales: Su, Fang-Yi, Zhao, Qingyang Henry, Dahotre, Shreyas N., Gamboa, Lena, Bawage, Swapnil Subhash, Silva Trenkle, Aaron D., Zamat, Ali, Phuengkham, Hathaichanok, Ahmed, Rafi, Santangelo, Philip J., Kwong, Gabriel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865765/
https://www.ncbi.nlm.nih.gov/pubmed/35196075
http://dx.doi.org/10.1126/sciadv.abm7950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865765/
https://www.ncbi.nlm.nih.gov/pubmed/35196075
http://dx.doi.org/10.1126/sciadv.abm7950

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