Activation of PDGFRA signaling contributes to filamin C–related arrhythmogenic cardiomyopathy

FLNC truncating mutations (FLNCtv) are prevalent causes of inherited dilated cardiomyopathy (DCM), with a high risk of developing arrhythmogenic cardiomyopathy. We investigated the molecular mechanisms of mutant FLNC in the pathogenesis of arrhythmogenic DCM (a-DCM) using patient-specific induced pl...

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Detalles Bibliográficos
Autores principales: Chen, Suet Nee, Lam, Chi Keung, Wan, Ying-Wooi, Gao, Shanshan, Malak, Olfat A., Zhao, Shane Rui, Lombardi, Raffaella, Ambardekar, Amrut V., Bristow, Michael R., Cleveland, Joseph, Gigli, Marta, Sinagra, Gianfranco, Graw, Sharon, Taylor, Matthew R.G., Wu, Joseph C., Mestroni, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865769/
https://www.ncbi.nlm.nih.gov/pubmed/35196083
http://dx.doi.org/10.1126/sciadv.abk0052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865769/
https://www.ncbi.nlm.nih.gov/pubmed/35196083
http://dx.doi.org/10.1126/sciadv.abk0052

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