PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer

The tumor-suppressor PTPN2 is diminished in a subset of triple-negative breast cancers (TNBCs). Paradoxically, PTPN2-deficiency in tumors or T cells in mice can facilitate T cell recruitment and/or activation to promote antitumor immunity. Here, we explored the therapeutic potential of targeting PTP...

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Detalles Bibliográficos
Autores principales: Goh, Pei Kee, Wiede, Florian, Zeissig, Mara N., Britt, Kara L., Liang, Shuwei, Molloy, Tim, Goode, Nathan, Xu, Rachel, Loi, Sherene, Muller, Mathias, Humbert, Patrick O., McLean, Catriona, Tiganis, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865802/
https://www.ncbi.nlm.nih.gov/pubmed/35196085
http://dx.doi.org/10.1126/sciadv.abk3338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865802/
https://www.ncbi.nlm.nih.gov/pubmed/35196085
http://dx.doi.org/10.1126/sciadv.abk3338

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