GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

BACKGROUND: Mitochondrial DNA copy number (mtDNA-CN) is an accessible blood-based measurement believed to capture underlying mitochondrial (MT) function. The specific biological processes underpinning its regulation, and whether those processes are causative for disease, is an area of active investi...

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Detalles Bibliográficos
Autores principales: Chong, Michael, Mohammadi-Shemirani, Pedrum, Perrot, Nicolas, Nelson, Walter, Morton, Robert, Narula, Sukrit, Lali, Ricky, Khan, Irfan, Khan, Mohammad, Judge, Conor, Machipisa, Tafadzwa, Cawte, Nathan, O'Donnell, Martin, Pigeyre, Marie, Akhabir, Loubna, Paré, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865845/
https://www.ncbi.nlm.nih.gov/pubmed/35023831
http://dx.doi.org/10.7554/eLife.70382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865845/
https://www.ncbi.nlm.nih.gov/pubmed/35023831
http://dx.doi.org/10.7554/eLife.70382

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