Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair(1). In microorganisms, transcription has been demonstrated to be mutagenic(2,3); however, the impact of transcription-associated mutagenesis...

Descripción completa

Detalles Bibliográficos
Autores principales: Reijns, Martin A. M., Parry, David A., Williams, Thomas C., Nadeu, Ferran, Hindshaw, Rebecca L., Rios Szwed, Diana O., Nicholson, Michael D., Carroll, Paula, Boyle, Shelagh, Royo, Romina, Cornish, Alex J., Xiang, Hang, Ridout, Kate, Schuh, Anna, Aden, Konrad, Palles, Claire, Campo, Elias, Stankovic, Tatjana, Taylor, Martin S., Jackson, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866115/
https://www.ncbi.nlm.nih.gov/pubmed/35140396
http://dx.doi.org/10.1038/s41586-022-04403-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866115/
https://www.ncbi.nlm.nih.gov/pubmed/35140396
http://dx.doi.org/10.1038/s41586-022-04403-y

Ejemplares similares