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Signatures of TOP1 transcription-associated mutagenesis in cancer and germline
The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair(1). In microorganisms, transcription has been demonstrated to be mutagenic(2,3); however, the impact of transcription-associated mutagenesis...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866115/ https://www.ncbi.nlm.nih.gov/pubmed/35140396 http://dx.doi.org/10.1038/s41586-022-04403-y |