Mechanism-based traps enable protease and hydrolase substrate discovery

Hydrolase enzymes, including proteases, are encoded by 2–3% of the genes in the human genome and 14% of these enzymes are active drug targets(1). However, the activities and substrate specificities of many proteases—especially those embedded in membranes—and other hydrolases remain unknown. Here we...

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Detalles Bibliográficos
Autores principales: Tang, Shan, Beattie, Adam T., Kafkova, Lucie, Petris, Gianluca, Huguenin-Dezot, Nicolas, Fiedler, Marc, Freeman, Matthew, Chin, Jason W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866121/
https://www.ncbi.nlm.nih.gov/pubmed/35173328
http://dx.doi.org/10.1038/s41586-022-04414-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866121/
https://www.ncbi.nlm.nih.gov/pubmed/35173328
http://dx.doi.org/10.1038/s41586-022-04414-9

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