Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice

Nonalcoholic fatty liver disease (NAFLD) affects a large population with incompletely defined mechanism(s). Here we report that Kindlin-2 is dramatically up-regulated in livers in obese mice and patients with NAFLD. Kindlin-2 haploinsufficiency in hepatocytes ameliorates high-fat diet (HFD)-induced...

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Detalles Bibliográficos
Autores principales: Gao, Huanqing, Zhou, Liang, Zhong, Yiming, Ding, Zhen, Lin, Sixiong, Hou, Xiaoting, Zhou, Xiaoqian, Shao, Jie, Yang, Fan, Zou, Xuenong, Cao, Huiling, Xiao, Guozhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866405/
https://www.ncbi.nlm.nih.gov/pubmed/35197460
http://dx.doi.org/10.1038/s41467-022-28692-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866405/
https://www.ncbi.nlm.nih.gov/pubmed/35197460
http://dx.doi.org/10.1038/s41467-022-28692-z

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