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Data-driven design of targeted gene panels for estimating immunotherapy biomarkers

Tumour mutation burden and other exome-wide biomarkers are used to determine which patients will benefit from immunotherapy. However, the cost of whole exome sequencing limits the widespread use of such biomarkers. Here, we introduce a data-driven framework for the design of targeted gene panels for...

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Detalles Bibliográficos
Autores principales: Bradley, Jacob R., Cannings, Timothy I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866421/
https://www.ncbi.nlm.nih.gov/pubmed/35197525
http://dx.doi.org/10.1038/s42003-022-03098-1