Transcriptome-guided identification of a four-component system, SbrH1-R, that modulates milbemycin biosynthesis by influencing gene cluster expression, precursor supply, and antibiotic efflux

Streptomyces can produce numerous antibiotics and many other bioactive compounds. Recently, the molecular mechanisms of transcriptional regulators in control of antibiotic production by influencing the expression of biosynthetic gene clusters (BGCs) have been extensively studied. However, for regula...

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Detalles Bibliográficos
Autores principales: Ye, Lan, Zhang, Yanyan, Li, Shanshan, He, Hairong, Ai, Guomin, Wang, Xiangjing, Xiang, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866680/
https://www.ncbi.nlm.nih.gov/pubmed/35261928
http://dx.doi.org/10.1016/j.synbio.2022.02.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866680/
https://www.ncbi.nlm.nih.gov/pubmed/35261928
http://dx.doi.org/10.1016/j.synbio.2022.02.003

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