Cargando…

Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis

Ferroptosis, a type of cell death triggered by excessive accumulation of iron-dependent lipid peroxidation, possesses an excellent potential in cancer treatment. However, many colorectal cancer (CRC) cell lines are resistant to ferroptosis induced by erastin and RSL3, the classical ferroptotic induc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Qian, Wei, Wanhui, Wu, Daiqian, Huang, Fengxing, Li, Mengting, Li, Wenjie, Yin, Jingwen, Peng, Yanan, Lu, Yuanyuan, Zhao, Qiu, Liu, Lan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866854/ https://www.ncbi.nlm.nih.gov/pubmed/35223839 http://dx.doi.org/10.3389/fcell.2022.810327

Ejemplares similares

Ferroptosis and ferritinophagy in diabetes complications
por: He, Jiahui, et al.
Publicado: (2022)

How erastin assassinates cells by ferroptosis revealed
por: Gan, Boyi
Publicado: (2022)

Arginine Expedites Erastin-Induced Ferroptosis through Fumarate
por: Guo, Xinxin, et al.
Publicado: (2023)

The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy
por: Zhao, Yuechen, et al.
Publicado: (2020)

Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia
por: Zhu, Ting, et al.
Publicado: (2021)

The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis
por: Yan, Renhong, et al.
Publicado: (2022)

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis
por: Wang, Yue-Qi, et al.
Publicado: (2016)

Nucleotide Variants of the BH4 Biosynthesis Pathway Gene GCH1 and the Risk of Orofacial Clefts
por: Hozyasz, Kamil K., et al.
Publicado: (2015)

Fascin enhances the vulnerability of breast cancer to erastin-induced ferroptosis
por: Chen, Cong, et al.
Publicado: (2022)

Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment
por: Sun, Kai, et al.
Publicado: (2022)

Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis
por: Shi, Hanqiang, et al.
Publicado: (2023)

Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis
por: Yu, Fan, et al.
Publicado: (2022)

Isoliquiritigenin attenuates septic acute kidney injury by regulating ferritinophagy-mediated ferroptosis
por: Tang, Yun, et al.
Publicado: (2021)

Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons
por: Zhang, Yan, et al.
Publicado: (2020)

Periodontitis-level butyrate-induced ferroptosis in periodontal ligament fibroblasts by activation of ferritinophagy
por: Zhao, Yunhe, et al.
Publicado: (2020)

Synergistic Effect of Erastin Combined with Nutlin-3 on Vestibular Schwannoma Cells as p53 Modulates Erastin-Induced Ferroptosis Response
por: He, Weiwei, et al.
Publicado: (2022)

Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH(4)/eNOS to Improve Intestinal Ischemia
por: Yan, Tao, et al.
Publicado: (2021)

TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells
por: Li, Kaiqiang, et al.
Publicado: (2022)

Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
por: Li, Wenxia, et al.
Publicado: (2022)

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
por: Masaldan, Shashank, et al.
Publicado: (2017)

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis
por: Fuhrmann, Dominik C., et al.
Publicado: (2020)

Liver injury in COVID-19: Holds ferritinophagy-mediated ferroptosis accountable
por: Jia, Feng-Ju, et al.
Publicado: (2022)

Saponin Formosanin C-Induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells
por: Lin, Pin-Lun, et al.
Publicado: (2020)

Stimulation of Hepatic Ferritinophagy Mitigates Irp2 Depletion-Induced Anemia
por: Liu, Yutong, et al.
Publicado: (2023)

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc(–)
por: Wang, Liyuan, et al.
Publicado: (2019)

Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC
por: Xue, Wei, et al.
Publicado: (2023)

Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating Nrf2
por: Zhou, Yizhao, et al.
Publicado: (2023)

Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells
por: Yu, Mengyu, et al.
Publicado: (2019)

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells
por: Qin, Xia, et al.
Publicado: (2021)

Monitoring and Regulating Intracellular GPX4 mRNA Using Gold Nanoflare Probes and Enhancing Erastin-Induced Ferroptosis
por: Liu, Xiaoyan, et al.
Publicado: (2022)

Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS–mitochondrial fission–mitophagy axis
por: Liu, Ming, et al.
Publicado: (2021)

Elabela: Negative Regulation of Ferroptosis in Trophoblasts via the Ferritinophagy Pathway Implicated in the Pathogenesis of Preeclampsia
por: Yang, Huan, et al.
Publicado: (2022)

Erastin-induced ferroptosis causes physiological and pathological changes in healthy tissues of mice
por: Zhao, Jing, et al.
Publicado: (2021)

Iron Administration Overcomes Resistance to Erastin-Mediated Ferroptosis in Ovarian Cancer Cells
por: Battaglia, Anna Martina, et al.
Publicado: (2022)

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
por: Savic, Dragana, et al.
Publicado: (2023)

L-phenylalanine attenuates high salt-induced hypertension in Dahl SS rats through activation of GCH1-BH(4)
por: Wang, Zhengjun, et al.
Publicado: (2021)

Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD
por: Zuo, Yong, et al.
Publicado: (2021)

NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells
por: Zhou, Hao, et al.
Publicado: (2022)

CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis
por: Jiang, Yang, et al.
Publicado: (2022)

Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells
por: Kan, Xianjin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7buqgj845gbl0d8sp8qtl86njk