Cargando…

Notch1 Modulation of Cellular Calcium Regulates Mitochondrial Metabolism and Anti-Apoptotic Activity in T-Regulatory Cells

As the major hub of metabolic activity and an organelle sequestering pro-apoptogenic intermediates, mitochondria lie at the crossroads of cellular decisions of death and survival. Intracellular calcium is a key regulator of these outcomes with rapid, uncontrolled uptake into mitochondria, activating...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saini, Neetu, Lakshminarayanan, Sowmya, Kundu, Priyanka, Sarin, Apurva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866856/ https://www.ncbi.nlm.nih.gov/pubmed/35222416 http://dx.doi.org/10.3389/fimmu.2022.832159

Ejemplares similares

Nucleolar localization of the Notch4 intracellular domain underpins its regulation of the cellular response to genotoxic stressors
por: Saini, Neetu, et al.
Publicado: (2020)

Sirtuin1 meditated modification of Notch1 intracellular domain regulates nucleolar localization and activation of distinct signaling cascades
por: Saini, Neetu, et al.
Publicado: (2022)

Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells
por: Marcel, Nimi, et al.
Publicado: (2016)

The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-x(L)
por: Parikh, Neha, et al.
Publicado: (2007)

Cellular Responses to the Efferocytosis of Apoptotic Cells
por: Yin, Charles, et al.
Publicado: (2021)

Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression
por: Lin, Yan, et al.
Publicado: (2018)

Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival
por: Saini, Neetu, et al.
Publicado: (2022)

The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion
por: Garg, M, et al.
Publicado: (2014)

Editorial: Current Concepts of Cellular and Biological Drugs to Modulate Regulatory T Cell Activity in the Clinic
por: Jonuleit, Helmut, et al.
Publicado: (2016)

Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer
por: Ferrandino, Francesca, et al.
Publicado: (2018)

Immune Tolerance to Apoptotic Self Is Mediated Primarily by Regulatory B1a Cells
por: Miles, Katherine, et al.
Publicado: (2018)

Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance
por: Szondy, Zsuzsa, et al.
Publicado: (2017)

Editorial: Current concepts of cellular and biological drugs to modulate regulatory T cell activity in the clinic, volume II
por: Wenger, Valentin, et al.
Publicado: (2023)

Anti-TNF-α agents Modulate SARS-CoV-2 Receptors and Increase the Risk of Infection Through Notch-1 Signaling
por: Keewan, Esra’a, et al.
Publicado: (2021)

Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune Hepatitis
por: Hao, Xiaohua, et al.
Publicado: (2018)

NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies
por: Kelliher, Michelle A., et al.
Publicado: (2018)

Calreticulin Release at an Early Stage of Death Modulates the Clearance by Macrophages of Apoptotic Cells
por: Osman, Rim, et al.
Publicado: (2017)

Human Apoptotic Cells, Generated by Extracorporeal Photopheresis, Modulate Allogeneic Immune Response
por: Pilon, Caroline, et al.
Publicado: (2019)

Identification of a Conserved Anti-Apoptotic Protein That Modulates the Mitochondrial Apoptosis Pathway
por: Zhang, Yu, et al.
Publicado: (2011)

The Linker Histone H1.2 Is an Intermediate in the Apoptotic Response to Cytokine Deprivation in T-Effectors
por: Garg, Megha, et al.
Publicado: (2014)

Mitochondrial Control and Guidance of Cellular Activities of T Cells
por: Chao, Tung, et al.
Publicado: (2017)

Plasmacytoid Dendritic Cells Respond Directly to Apoptotic Cells by Secreting Immune Regulatory IL-10 or IFN-α
por: Simpson, Joanne, et al.
Publicado: (2016)

The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
por: Zhang, Linlin, et al.
Publicado: (2022)

Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction
por: Piccinni, Marie-Pierre, et al.
Publicado: (2021)

Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2
por: Gentek, Rebecca, et al.
Publicado: (2013)

Different Interleukin-1β Converting Enzyme (ICE) Family Protease Requirements for the Apoptotic Death of T Lymphocytes Triggered by Diverse Stimuli
por: Sarin, Apurva, et al.
Publicado: (1996)

A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells
por: Steinbuck, Martin Peter, et al.
Publicado: (2018)

CD4+CD25+CD127(low) Regulatory T Cells Play Predominant Anti-Tumor Suppressive Role in Hepatitis B Virus-Associated Hepatocellular Carcinoma
por: Sharma, Shreya, et al.
Publicado: (2015)

Extracellular Adenosine-Mediated Modulation of Regulatory T Cells
por: Ohta, Akio, et al.
Publicado: (2014)

Inhibition of Notch1 Signaling Alleviates Endotoxin-Induced Inflammation Through Modulating Retinal Microglia Polarization
por: Cheng, Zhixing, et al.
Publicado: (2019)

Oxalate Alters Cellular Bioenergetics, Redox Homeostasis, Antibacterial Response, and Immune Response in Macrophages
por: Kumar, Parveen, et al.
Publicado: (2021)

Modulation of T Cell Metabolism and Function through Calcium Signaling
por: Fracchia, Kelley M., et al.
Publicado: (2013)

Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome
por: Radic, Marko, et al.
Publicado: (2018)

Exploitation of Apoptotic Regulation in Cancer
por: Ucker, David S., et al.
Publicado: (2018)

Apoptotic Donor Cells in Transplantation
por: Husain, Irma, et al.
Publicado: (2021)

The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells
por: Gregori, Silvia, et al.
Publicado: (2012)

Regulatory mechanisms of mitochondrial calcium uptake by the calcium uniporter complex
por: Yamada, Akiko, et al.
Publicado: (2023)

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium
por: Hirano, Ken-ichi, et al.
Publicado: (2022)

NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling
por: López-López, Susana, et al.
Publicado: (2021)

Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries
por: Oghumu, Steve, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cpoflgfijd3h1sj2mtsp4iv232