Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain

The human serotonin transporter (hSERT) terminates neurotransmission by removing serotonin (5HT) from the synaptic cleft, an essential process for proper functioning of serotonergic neurons. Structures of the hSERT have revealed its molecular architecture in four conformations, including the outward...

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Detalles Bibliográficos
Autores principales: Gradisch, Ralph, Szöllősi, Dániel, Niello, Marco, Lazzarin, Erika, Sitte, Harald H., Stockner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867121/
https://www.ncbi.nlm.nih.gov/pubmed/35065961
http://dx.doi.org/10.1016/j.jbc.2022.101613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867121/
https://www.ncbi.nlm.nih.gov/pubmed/35065961
http://dx.doi.org/10.1016/j.jbc.2022.101613

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